Process monitoring of an industrial fed-batch fermentation
نویسندگان
چکیده
منابع مشابه
Modelling of a Fed-Batch Fermentation Process
This report describes the building of a simulator for prediction of the dissolved oxygen concentration, the oxygen transfer rate and the concentration of carbon dioxide in a fermentation process. The steady state models were made using the linguistic equations method. The dynamic models were made using Simulink ® toolbox in the Matlab ® . At the beginning, some basics about fermentation and mic...
متن کاملStatistical Process Monitoring of Industrial Batch Processes
The manufacture of high-value products involves many different batch processes, for example industrial fermenters. Such processes require high levels of consistency in their operation to ensure minimal losses of raw materials, utilities and product. Recent application studies have indicated that multivariate statistical technology can provide some support when trying to maintain consistent oper...
متن کاملOptimal switching control of a fed-batch fermentation process
Considering the hybrid nature in fed-batch culture of glycerol biconversion to 1,3-propanediol (1,3-PD) by Klebsiella pneumoniae, we propose a state-based switching dynamical system to describe the fermentation process. To maximize the concentration of 1,3-PD at the terminal time, an optimal switching control model subject to our proposed switching system and constraints of continuous state ine...
متن کاملBatch-to-Batch Iterative Learning Control of a Fed-batch Fermentation Process Using Incrementally Updated Models
Batch-to-batch iterative learning control of a fed-batch fermentation process using batchwise linearised models identified from process operation data is presented in this paper. Due to model-plant mismatches and the present of unknown disturbances, off-line calculated control policy may not be optimal when implemented to the real process. The repetitive nature of batch process allows informati...
متن کاملOxygen Control for an Industrial Pilot-scale Fed-batch Filamentous Fungal Fermentation
Industrial filamentous fungal fermentations are typically operated in fed-batch mode. Oxygen control represents an important operational challenge due to the varying biomass concentration. In this study, oxygen control is implemented by manipulating the substrate feed rate, i.e. the rate of oxygen consumption. It turns out that the setpoint for dissolved oxygen represents a trade-off since a lo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biotechnology and Bioengineering
سال: 2001
ISSN: 0006-3592,1097-0290
DOI: 10.1002/bit.1102